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If tumor cells activate the homologous recombination repair pathway by upregulating key repair proteins (such as BRCA1/2, RAD51, etc.), they can efficiently repair these serious damages and thus escape chemotherapy induced cell apoptosis (Casolino et al., 2021)
Some studies suggest splitting the dose into two smaller amounts for better efficacy
Anyone quoting you a clean 95% oral bioavailability number for humans is repeating a marketing figure, not something from the literature
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